Cefpodoxime
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Cefpodoxime
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| Systematic (IUPAC) name | |
| (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)- 2-methoxyimino-acetyl]amino}-3-(methoxymethyl)- 8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid |
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| Identifiers | |
| CAS number | 82619-04-3 |
| ATC code | J01DD13 |
| PubChem | 6335986 |
| Chemical data | |
| Formula | C15H17N5O6S2 |
| Mol. weight | 427.458 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 50% |
| Protein binding | 21% to 29% |
| Metabolism | Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver |
| Half life | 2 hours |
| Excretion | Renal, unchanged |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status |
℞-only(US) |
| Routes | Oral |
Cefpodoxime (marketed as the prodrug cefpodoxime proxetil by Pharmacia & Upjohn under the trade name Vantin®) is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.
[edit] External links
- PubChem 6526396 - cefpodoxime proxetil
- Vantin Tablets and Oral Suspension Full U.S. Prescribing Information (from manufacturer's website)
| Cephalosporin Antibiotics (J01D) edit | ||
|---|---|---|
| First Generation: |
Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefalonium, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazaflur, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole |
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| Second Generation: |
Cefaclor, Cefamandole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime, Cefuzonam |
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| Third Generation: |
Cefcapene , Cefdaloxime, Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpimizole, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Cefteram, Ceftibuten, Ceftiofur, Ceftiolene, Ceftizoxime, Ceftriaxone, Latamoxef |
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| Fourth Generation: |
Cefclidine, Cefepime, Cefetecol, Cefluprenam, Cefoselis, Cefozopran, Cefpirome, Cefquinome |
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