Cefotiam
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Cefotiam
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| Systematic (IUPAC) name | |
| (6R,7R)-7-{[2-(2-amino-1,3-thiazol-4-yl)acetyl] amino}-3-{[1-(2-dimethylaminoethyl)tetrazol-5-yl] sulfanylmethyl}-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid |
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| Identifiers | |
| CAS number | 61622-34-2 |
| ATC code | J01DC07 |
| PubChem | 43708 |
| DrugBank | APRD00855 |
| Chemical data | |
| Formula | C18H23N9O4S3 |
| Mol. weight | 525.631 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 60% (intramuscular) |
| Protein binding | 40% |
| Metabolism | Nil |
| Half life | Approximately 1 hour |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | Intravenous, intramuscular |
Cefotiam is a second-generation cephalosporin antibiotic.
[edit] External links
- Müller R, Böttger C, Wichmann G (2003). "Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients.". Arzneimittelforschung 53 (2): 126-32. PMID 12642969.
- Kolben M, Mandoki E, Ulm K, Freitag K (2001). "Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section.". Eur J Clin Microbiol Infect Dis 20 (1): 40-2. PMID 11245321.
- Shimizu S, Chen K, Miyakawa S (1996). "Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses.". Dermatology 192 (2): 174-6. PMID 8829507.
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| Cephalosporin Antibiotics (J01D) edit | ||
|---|---|---|
| First Generation: |
Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefalonium, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazaflur, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole |
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| Second Generation: |
Cefaclor, Cefamandole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime, Cefuzonam |
|
| Third Generation: |
Cefcapene , Cefdaloxime, Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpimizole, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Cefteram, Ceftibuten, Ceftiofur, Ceftiolene, Ceftizoxime, Ceftriaxone, Latamoxef |
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| Fourth Generation: |
Cefclidine, Cefepime, Cefetecol, Cefluprenam, Cefoselis, Cefozopran, Cefpirome, Cefquinome |
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