Cefdinir

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Cefdinir
Systematic (IUPAC) name
8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso- ethenyl]amino-4-ethenyl-7-oxo-2-thia-6- azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
Identifiers
CAS number	91832-40-5
ATC code	J01DD15
PubChem	6399253
DrugBank	APRD00644
Chemical data
Formula	C14H13N5O5S2
Mol. weight	395.416 g/mol
Pharmacokinetic data
Bioavailability	16% to 21% (dose-dependent)
Protein binding	60% to 70%
Metabolism	Negligible
Half life	1.7 ± 0.6 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status	℞-only(US)
Routes	Oral

Cefdinir (marketed by Abbott Laboratories under the brand name Omnicef®) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA) in December of 1997.

Contents 1 Mechanism of action 2 Indications 2.1 Susceptible organisms 2.1.1 Gram-negative 2.1.2 Gram-positive 3 Side effects 4 Available forms and dosage 5 References 6 External links

[edit] Mechanism of action

Main article: Cephalosporin

[edit] Indications

Therapeutic uses of cefdinir include otitis media, soft tissue infections, and respiratory tract infections, including community-acquired pneumonia and exacerbations of bronchitis.

[edit] Susceptible organisms

Cefdinir is a bacteriocidal antibiotic. It can be used to treat infections caused by several Gram-negative and Gram-positive bacteria, including:

[edit] Gram-negative

• Haemophilus influenzae
• Moraxella catarrhalis
• Escherichia coli
• Klebsiella spp.
• Proteus mirabilis

[edit] Gram-positive

• Staphylococcus aureus
• Streptococcus pneumoniae
• Streptococcus pyogenes

Like most third-generation cephalosporins, cefdinir is not an effective treatment against infections caused by Pseudomonas aeruginosa.

[edit] Side effects

According to the Omnicef website, side effects include "(...) diarrhea, vaginal infections or inflammation, nausea, headache, and abdominal pain."^[1]

[edit] Available forms and dosage

Cefdinir is administered orally. It is available as capsules and a suspension. Dosage, schedule, and duration of therapy varies according to the type of infection. For adults, the average dosage is between 300 and 600 mg per 12 or 24 hour period, for the duration of between 5 and 10 days. Average pediatric dosage is between 7 and 14 mg/kg (schedule and duration the same as adult).

[edit] References

[edit] External links

• Omnicef homepage

Cephalosporin Antibiotics (J01D) edit
First Generation:	Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefalonium, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazaflur, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole
Second Generation:	Cefaclor, Cefamandole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime, Cefuzonam
Third Generation:	Cefcapene , Cefdaloxime, Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpimizole, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Cefteram, Ceftibuten, Ceftiofur, Ceftiolene, Ceftizoxime, Ceftriaxone, Latamoxef
Fourth Generation:	Cefclidine, Cefepime, Cefetecol, Cefluprenam, Cefoselis, Cefozopran, Cefpirome, Cefquinome