CD38

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CD38 molecule
Identifiers
Symbol(s)	CD38
Entrez	952
OMIM	107270
RefSeq	NM_001775
UniProt	P28907
Other data
Locus	Chr. 4 [1]

CD38 (cluster of differentiation 38) is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It is a marker of cell activation. The CD38 protein has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions. It has also been used as a prognostic marker in leukemia.

The gene encoding for CD38 is located on chromosome 4.

[edit] References

• Deaglio S, Mehta K, Malavasi F (2001). "Human CD38: a (r)evolutionary story of enzymes and receptors". Leuk Res 25 (1): 1-12. PMID 11137554.