Cathepsins

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Cathepsins are a large family of lysosomal cysteine proteases that have a vital role in mammalian cellular turnover, e.g. bone resorption. They degrade polypeptides and are distinguished by their substrate specificites. Cathepsin K, which is defined by its high specificity for kinins, is involved in bone resorption. Cathepsin K's ability to catabolize elastin, collagen, and gelatin allow it to break down bone and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil in Emphysema. Cathepsin K "blockers" show great potential in the treatment of osteoporosis. Cathepsin K expression is stimulated by inflammatory cytokines that are released after tissue injury.

See Cathepsin