Captopril challenge test

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In medicine, the captopril challenge test, also CCT, is a non-invasive test used to help diagnose renal artery stenosis.

The CCT, in adults, has a high sensitivity, but a low specificity.[1] A better test for diagnosing renal artery stenosis is subtraction renal angiography.[2]

[edit] How it is done

The CCT is performed by measuring the renin prior to and following the administration of captopril, an angiotensin converting enzyme inhibitor. A CCT is considered positive if the renin levels increase substaintially or the baseline renin level is abnormally high.[3]

[edit] Use of the CCT in children

The CCT has not been found to be very useful in children.[4]

[edit] References

  1. ^ Bales A. Hypertensive crisis. How to tell if it's an emergency or an urgency. Postgrad Med. 1999 May 1;105(5):119-26, 130. PMID 10335324. Free Full Text.
  2. ^ Svetkey LP, Himmelstein SI, Dunnick NR, Wilkinson RH Jr, Bollinger RR, McCann RL, Beytas EM, Klotman PE. Prospective analysis of strategies for diagnosing renovascular hypertension. Hypertension. 1989 Sep;14(3):247-57. PMID 2670763.
  3. ^ Muller FB, Sealey JE, Case DB, Atlas SA, Pickering TG, Pecker MS, Preibisz JJ, Laragh JH. The captopril test for identifying renovascular disease in hypertensive patients. Am J Med. 1986 Apr;80(4):633-44. PMID 3515933.
  4. ^ Gauthier B, Trachtman H, Frank R, Pillari G. Inadequacy of captopril challenge test for diagnosing renovascular hypertension in children and adolescents. Pediatr Nephrol. 1991 Jan;5(1):42-4. PMID 2025535.
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