C4BPA (protein)

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complement component 4 binding protein, alpha
Identifiers
Symbol(s) C4BPA C4BP
Entrez 722
OMIM 120830
RefSeq NM_000715
UniProt P04003
Other data
Locus Chr. 1 q32

C4BPB is a protein involved in the complement system. It inhibits the action of C4. C4BP has a hydra-like structure with a central stalk and seven branching alpha-chains. It splits C4 convertase and is a cofactor for factor I which cleaves C4b. C4BP binds necrotic cells and DNA, to clean up after inflammation. It also binds CD40 on B cells which potentiaties proliferation and costimulation.

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Complement system - edit

Activators: C6 | C7 | C9 | MBL2 | PFC
Complexes: C1Q (C1QA, C1QB, C1QG) | C3-convertase | C8 (C8A, C8B, C8G) | MAC
Enzymes: BF | C1R | C1S | C2 | C3 | C4 | C5 | DF | MASP1 | MASP2
Inhibitors: C1inh | C4BP (C4BPA, C4BPB) | CLU | DAF | HF1 | IF | SERPING1 | VTN
Receptors: C3AR1 | C5R1 | CR1 | CR2 | ITGAM
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