C1 domain
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C1 domain (also knowbn as phorbol esters/diacylglycerol binding domain) binds an important secondary messenger diacylglycerol (DAG).
Phorbol esters (PE) are analogues of DAG and potent tumor promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC). Phorbol esters can directly stimulate PKC.
The N-terminal region of PKC, known as C1, binds PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PE-binding.
The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.
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| Protein domains: |
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| BZIP | DED | Kringle | PH | SH2 | SH3 | zinc finger | coiled coil | helix bundle | globin fold | twisted open sheet | alpha/beta barrels | up and down barrel | greek key barrel | jelly roll barrel | greek key | leucine-rich repeat | beta propeller |
