C-Jun N-terminal kinases

From Wikipedia, the free encyclopedia

mitogen-activated protein kinase 8
Identifiers
Symbol(s)	MAPK8 PRKM8
Entrez	5599
OMIM	601158
RefSeq	NM_002750
UniProt	P45983
Other data
Locus	Chr. 10 q11.2

mitogen-activated protein kinase 9
Identifiers
Symbol(s)	MAPK9 PRKM9
Entrez	5601
OMIM	602896
RefSeq	NM_002752
UniProt	P45984
Other data
Locus	Chr. 5 q35

mitogen-activated protein kinase 10
Identifiers
Symbol(s)	MAPK10 PRKM10
Entrez	5602
OMIM	602897
RefSeq	NM_002753
UniProt	P53779
Other data
Locus	Chr. 4 q22-q23

C-Jun N-terminal kinases (JNKs) are mitogen-activated protein kinases which are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation and apoptosis. The c-Jun N-terminal of MAPK consists of three isoforms. JNK1 and JNK2 are ubiquitinous distributed and JNK3 is found in neuronal tissue. The JNK-1 is involved in inflammatory conditions and cytokine production mediated by AP-1 (Activation Protein 1) such as RANTES, IL-8 and GM-CSF.