Bumetanide
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Bumetanide
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| Systematic (IUPAC) name | |
| 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid | |
| Identifiers | |
| CAS number | 28395-03-1 |
| ATC code | C03CA02 |
| PubChem | 2471 |
| DrugBank | APRD00294 |
| Chemical data | |
| Formula | C17H20N2O5S |
| Mol. weight | 364.417 g/mol |
| Pharmacokinetic data | |
| Bioavailability | almost complete |
| Protein binding | 97% |
| Metabolism | hepatic |
| Half life | 60-90 minutes |
| Excretion | renal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | oral |
Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche with the brand name Bumex. There is however no reason not to use bumetanide as a first choice drug. The main difference between the two substances is in bioavailability. Furosemide is incompletely absorbed in the intestine (40%), and there is substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.
Bumetanide is 40 times more potent than furosemide (for patients with normal renal function).
[edit] External links
- Bumex (manufacturer's website)
- Bumetanide (patient information)
| Antihypertensives (C02) and diuretics (C03) edit | ||
|---|---|---|
| Antiadrenergic agents (including alpha): |
Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine |
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| Vasodilators: |
Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine |
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| Other antihypertensives: | ||
| Low ceiling diuretics: |
Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine |
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| High ceiling diuretics: |
Bumetanide, Furosemide, Torasemide |
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| Potassium-sparing diuretics: | ||
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