Budesonide/formoterol

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Unopened Symbicort Turbuhaler (left) and opened (middle and right)
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Unopened Symbicort Turbuhaler (left) and opened (middle and right)

The combination preparation budesonide/formoterol is a formulation containing budesonide and formoterol used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is marketed by AstraZeneca under the trade name Symbicort.

Symbicort contains two active ingredients which delivered via a single inhaler:

Currently it is available in three doses of 100/6, 200/6 and 400/12, where the larger number is the dose per actuation of budesonide (in milligrams) and the lower number the dose of formoterol. Symbicort was introduced in Sweden in 2000 and is approved for use in at least 70 countries, yielding global sales in excess of $1 billion in 2005. It was not approved for use in the United States until July 2006.[1]

Symbicort is the first combination inhaled corticosteroid/long-acting beta agonist (ICS/LABA) that has shown some efficacy as a medicine not only used to prevent asthma attacks, but also provide quick relief of an asthma attack.[2][3] The use for quick relief has not yet been approved by any guidelines, government or committee.

[edit] References

[edit] Notes

  1. ^ Haber, Gary. "AstraZeneca banking on asthma inhaler", Delaware News-Journal (delawareonline), November 19, 2006.
  2. ^ Balanag, VM, Yunus F, Yang PC, Jorup C (April 2006). "Efficacy and safety of budesonide/formoterol compared with salbutamol in the treatment of acute asthma". Pulmonary Pharmacology & Therapeutics 19 (2): 139–147. DOI:10.1016/j.pupt.2005.04.009. PMID 16009588. Retrieved on 9 June 2006.
  3. ^ Vogelmeier, C, D'Urzo A, Pauwels R, Merino JM, Jaspal M, Boutet S, Naya I, Price D (November 2005). "Budesonide/formoterol maintenance and reliever therapy: an effective asthma treatment option?". European Respiratory Journal 26 (5): 819–828. PMID 16264042.

[edit] See also


Medications commonly used in asthma and COPD (primarily R03) edit
Anticholinergics:

Ipratropium, Tiotropium

Short acting β2-agonists:

Salbutamol, Terbutaline

Long acting β2-agonists (LABA): Clenbuterol, Formoterol, Salmeterol
Corticosteroids:

Beclometasone, Budesonide, Fluticasone

Leukotriene antagonists:

Montelukast, Pranlukast, Zafirlukast

Xanthines:

Aminophylline, Theobromine, Theophylline

Mast cell stabilizers:

Cromoglicate, Nedocromil

Combination products:

Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol