Brinzolamide

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Brinzolamide
Systematic (IUPAC) name
(5R)-5-ethylamino-3-(3-methoxypropyl)- 2,2-dioxo-2λ6,9-dithia- 3-azabicyclo[4.3.0]nona-7,10-diene- 8-sulfonamide
Identifiers
CAS number	138890-62-7
ATC code	S01EC04
PubChem	68844
DrugBank	APRD00475
Chemical data
Formula	C12H21N3O5S3
Mol. weight	383.51 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	~60%
Metabolism	?
Half life	111 days
Excretion	?
Therapeutic considerations
Licence data	EU US
Pregnancy cat.	C(US)
Legal status	℞-only(US)
Routes	Opthalmic

Brinzolamide is a carbonic anhydrase inhibitor.

[edit] References

• Ermis S, Ozturk F, Inan U (2005). "Comparing the effects of travoprost and brinzolamide on intraocular pressure after phacoemulsification.". Eye 19 (3): 303-7. PMID 15258611.
• Iester M, Altieri M, Michelson G, Vittone P, Traverso C, Calabria G. "Retinal peripapillary blood flow before and after topical brinzolamide.". Ophthalmologica 218 (6): 390-6. PMID 15564757.
• Kaup M, Plange N, Niegel M, Remky A, Arend O (2004). "Effects of brinzolamide on ocular haemodynamics in healthy volunteers.". Br J Ophthalmol 88 (2): 257-62. PMID 14736787.

Antiglaucoma preparations and miotics (S01E) edit
Sympathomimetics:	Apraclonidine, Brimonidine, Clonidine, Dipivefrine, Epinephrine
Parasympathomimetics:	Aceclidine, Acetylcholine, Carbachol, Demecarium, Echothiophate, Fluostigmine, Neostigmine, Paraoxon, Physostigmine, Pilocarpine
Carbonic anhydrase inhibitors:	Acetazolamide, Brinzolamide, Diclofenamide, Dorzolamide, Methazolamide
Beta blocking agents:	Befunolol, Betaxolol, Carteolol, Levobunolol, Metipranolol, Timolol
Prostaglandin analogues:	Bimatoprost, Latanoprost, Travoprost, Unoprostone
Other agents:	Dapiprazole, Guanethidine