Talk:Blepharitis

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[edit] Fungal treatments for blepharitis

This would need verification and citing, but it does not seem generally supported by the current evidence. Searching PubMed yields just 5 references for "Blepharitis Ketoconazole" (or "Blepharitis Nizorel") in the last 25 years !

1. Derbel M, Benzina Z, Ghorbel I, Abdelmoula S, Makni F, Ayadi A, Feki J (2005). "[Malassezia fungal blepharitis: a case report]". J Fr Ophtalmol 28 (8): 862-5. PMID 16249768. - acknowledges "the role of certain mycoses in the etiopathogenesis of blepharitis remains controversial"
2. Maichuk IuF, Lapshina NA, Diadina UV (1991). "[Imidazoles in the treatment of ocular mycoses]". Antibiot Khimioter 36 (1): 45-6. PMID 1905126. - listing summary of a number of trials and totally just 40 patients - hardly common
3. Nelson ME, Midgley G, Blatchford NR (1990). "Ketoconazole in the treatment of blepharitis". Eye 4 ( Pt 1): 151-9. PMID 2138985. - "Ketoconazole was no better than placebo at improving the symptoms of blepharitis."
4. Rysselaere M (1983). "Blepharitis by Microsporum canis". Bull Soc Belge Ophtalmol 207: 93-6. PMID 6093916. - is a case report, but has no PubMed summary
5. Rodenbiker HT, Ganley JP (1980). "Ocular coccidioidomycosis". Surv Ophthalmol 24 (5): 263-90. PMID 6988997. - describes fungal infection of the eye itself, rather than external eyelid problem.

So please cite evidence either that dermatologists commonly recomend such treatment (its not on Moorfields Eye Hospital's info sheet) or studies of effectiveness. David Ruben ^Talk 19:35, 13 March 2006 (UTC)

[edit] Don't forget Rosacea associated blepharatis - the most common variant

Most of the thinking in regards to blepharitis has undergone a transformation in the last decade. Many people are of the opinion that the most typical form of blepharitis has little to do with colonizing bacteria and everything to do with an immune overeaction at the oil gland outlets (meibomian glands). Blepharitis is commonly found in association with acne rosacea and it is belived that the same glandular inflamatory process that affects the facial skin is affecting the lid skin.

The most high yield treatment for this type of rosacea associated blepharitis is warm compress - lid scrubbing with shampoo seems to make little difference. Use of antibiotic is mostly uneccessary and occasionally harmful when toxicity develops to the medication. The use of lubrication such as artificial tears is also a mainstay of therapy.

Resistant cases are treated with topical stearoid preparations for a limited interval and sometimes oral agents in the tetracycline family (tetracycline, doxycycline, minocycline) can be very effective both for the blepharatis and rosacea.—The preceding unsigned comment was added by 24.207.24.95 (talk • contribs) 16:28, 18 August 2006 (UTC).