Blaise ketone synthesis

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The Blaise ketone synthesis is the chemical reaction of acid chlorides with organozinc compounds to give ketones.^{[1] [2]}

The reaction also works with organocuprates.^[3][4]

Reviews have been written.^{[5] [6]}

Contents 1 Variations 1.1 Blaise-Maire reaction 2 References 3 See also

[edit] Variations

[edit] Blaise-Maire reaction

The Blaise-Maire reaction is the Blaise ketone synthesis using β-hydroxy acid chlorides to give β-hydroxyketones, which are converted into α,β-unsaturated ketones using sulfuric acid.^[7]

[edit] References

1. ↑  Blaise, E. E.; Koehler, A. Bull. Soc. Chim. 1910, 7, 215.
2. ↑  Blaise, E. E. Bull. Soc. Chim. 1911, 9, 1.
3. ↑  Posner, G. H.; Whitten, C. E. Organic Syntheses, Coll. Vol. 6, p.248 (1988); Vol. 55, p.122 (1976). (Article)
4. ↑  Fujisawa, T.; Sato, T. Organic Syntheses, Coll. Vol. 8, p.441 (1993); Vol. 66, p.116 (1988). (Article)
5. ↑  Cason, J. Chem. Rev. 1947, 40, 17. (Review)
6. ↑  Shirley, D. A. Org. React. 1954, 8, 29. (Review)
7. ↑  Blaise, E. E.; Maire, M. Compt. Rend. 1907, 145, 73.

[edit] See also

• Blaise reaction