Talk:Bisphosphonate
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This article mentions that bisphosphonate is synonymous with diphosphonate. I'm not a pharmacologist, but aren't these distinct classes of molecules (biochemically-speaking)? I'm thinking of the difference between bisphosphate and diphosphate — bis refers to phosphates separately bound to a parent group, while di refers to a chain of phosphates linked to the parent group. I'd suspect that the same terminology applies here as well. Of course, maybe I just can't recall enough college biochem ;-) --Diberri | Talk 23:19, May 20, 2004 (UTC)
[edit] Diphosphate definition
Diphosphate: An ester of phosphoric acid containing two phosphate groups.
Source: The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2000 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved. http://dictionary.reference.com/search?r=66&q=diphosphate
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- Bisphosphonate is the chemically correct name for the drug. They were originally designed as analogues of pyrophosphate and incorrectly named disphosphonate. The disphosphonate name is historical, but I think it is useful that it is cited here. Dr Aaron 23:41, 9 July 2006 (UTC)
The side effects section of this page requires a citation. The listed frequencies for the osteonecrosis of the jaw side-effect are contradicted in this article at NYTimes.com ( http://www.nytimes.com/2006/06/02/health/02jaw.html?hp&ex=1149307200&en=add01a0366c2bcf3&ei=5094&partner=homepage).
This article states that reliable data on the frequency of the noted side-effect are non-existent. As such the list frequency (80% for some situations) may be a misleading and cause undue panic about these drugs. The frequency cited in this article is 1-10% for cancer patients, because they recieve higher doses (likely by IV), and this data is considered uncertain (as indicated by such a large range). 63.251.131.90 13:31, 2 June 2006 (UTC) --Mercutio.Wilder 13:34, 2 June 2006 (UTC)
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- ONJ (osteonecrosis of the jaw) is a relatively new phenomenon. Based on discussion at the "What's New in Bisphosphonates" conference in Davos Switzerland (2006), it was generally agreed that it is a real effect, although there is debate on how common it is. As far as I'm aware, virtually all the cases of bisphosphonate-induced ONJ are associated with dental extractions in cancer patients. Dr Aaron 23:41, 9 July 2006 (UTC)
We need to be vary careful how we present this. Dr Zak (talk • contribs) has tried to link osteonecrosis of the jaw to osteonecrosis or to phossy jaw. Both are related but different conditions, and I suspect we need a new article to document this phenomenon. Phossy jaw is (by definition) caused by white phosphorus, and osteonecrosis of other bones has not been linked to bisphonates. The evidence is quite incontrovertible; if there is a view that states that cancer patients have abnormal bone metabolism (especially in myeloma) we should cover this too. JFW | T@lk 10:37, 26 July 2006 (UTC)
