Bis-tris methane

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Bis-tris methane

General
Systematic name	2-[Bis-(2-hydroxyethyl)-amino]- 2-hydroxymethyl-propane-1,3-diol
Other names	Bis-tris Bis-(2-hydroxy-ethyl)- amino-tris(hydroxymethyl)-methane 2,2-Bis(hydroxymethyl)- 2,2,2-nitrilotriethanol
Molecular formula	C₈H₁₉NO₅
Molar mass	209.2418 g/mol
Appearance	white crystalline powder
CAS number	[6976-37-0] [1]
SMILES	OCC(CO)(N(CCO)CCO)CO
Properties
Density and phase	? g/l, solid (25°C)
Solubility in water	67? g/100 ml (20°C)
Melting point	102-106°C (375-379K)
Boiling point	?°C (?K)
Acidity (pK_a)	5.80-7.30 @25°C
Hazards
MSDS	External MSDS
Main hazards	Irritant.
NFPA 704	0 2 0
Flash point	Non-flammable.
R/S statement	R: R36, R37, R38. S: S26, S36.
RTECS number	TY2900000


Except where noted otherwise, data are given for materials in their standard state (at 25°C, 100 kPa) Infobox disclaimer and references

Bis-tris is an abbreviation of the trivial name (Bis(2-hydroxyethyl)-imino-tris(hydroxymethyl)-methane) for 2-[Bis(2-hydroxyethyl)imino]-2-(hydroxymethyl)-1,3-propanediol. It is generally used as a buffering agent in biochemistry. Bis-tris is an organic tertiary amine with labile protons having a pKa of 6.46 at 25°C. It is an effective buffer between the pH 5.8 and 7.3.