Talk:Bioavailability

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[edit] Ecological Bioavailability

Can we have a discussion about bioavailability in the context of ecology? For instance, what it means for a particular molecule to be bioavailable to a microbe. I think this is an important definition of bioavailability, though, I'm not the one to define it. Any takers?

--Jen Duane 08:28, 15 November 2005 (UTC)

[edit] Explanation please...

In the formula for Absolute Availability: F = \frac{[AUC]_{po}*dose_{IV}}{[AUC]_{IV}*dose_{po}}, what does the 'po' mean? I guess it is related to 'extra-vascular', but it is not obvious.

What does the 'dose-corrected AUC' mean?

Hi Duncan.france, "po" is conventional medical abbreviation for per os (by mouth). It made more sense when I originally wrote this article, because (to keep things simple) I only referred to absolute bioavailability of orally-administered drugs. But since people have added comments about other extravascular routes, I've now modified the text to try to explain. Dose corrected AUC means that doses of the drug given IV or non-IV can be different, so the formula for calculating F takes this into account. Hope that helps – let me know if it needs to be clarified further in the text. -Techelf 09:14, 20 March 2006 (UTC)

the formula is wrong... see http://www.chm.davidson.edu/erstevens/AUC/AUC.html

The page you cite actually just contains another way of expressing the same formula (think about it)... -Techelf 10:56, 4 April 2006 (UTC)
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