Biophysics

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Biophysics (also biological physics) is an interdisciplinary science that applies the theories and methods of physics, to questions of biology.

Biophysics research today comprises a number of specific biological studies, which do not share a unique identifying factor, nor subject themselves to clear and concise definitions. The studies included under the umbrella of biophysics range from sequence analysis to neural networks. In the recent past, biophysics included creating mechanical limbs and nanomachines to regulate biological functions. Nowadays, these are more commonly referred to as belonging to the fields of bioengineering and nanotechnology respectively.

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[edit] Overview

Traditional studies in biochemistry and molecular biology are conducted using statistical ensemble experiments, typically using pico- to micro-molar concentrations of macromolecules. Because the molecules that comprise living cells are so small, techniques such as PCR amplification, gel blotting, fluorescence labeling and in vivo staining are used so that experimental results are observable with an unaided eye or, at most, optical magnification. Using these techniques, researchers in these subjects attempt to elucidate the complex systems of interactions that give rise to the processes that make life possible.

Biophysics, in contrast, typically addresses similar biological questions, but the questions are asked at a molecular level. By drawing knowledge and experimental techniques from a wide variety of disciplines (as described below), biophysicists are able to indirectly observe or model the structures and interactions of individual molecules or complexes of molecules.

In addition to things like solving a protein structure or measuring the kinetics of single molecule interactions, biophysics is also understood to encompass research areas that apply models and experimental techniques derived from physics (e.g. electromagnetism and quantum mechanics) to larger systems such as tissues or organs (hence the inclusion of basic neuroscience as well as more applied techniques such as fMRI).

Biophysics often does not have university-level departments of its own, but have presence as groups across departments within the fields of biology, biochemistry, chemistry, computer science, mathematics, medicine, pharmacology, physiology, physics, and neuroscience. What follows is a list of examples of how each department applies its efforts toward the study of biophysics. This list is hardly all inclusive. Nor does each subject of study belong exclusively to any particular department. Each academic institution makes its own rules and there is much mixing between departments.

Many biophysical techniques are unique to this field. Many of the research traditions in biophysics were initiated by scientists who were straight physicists, chemists, and biologists by training.

[edit] Topics in biophysics and related fields

[edit] Famous biophysicists

[edit] Other notable biophysicists

[edit] References

  • Perutz M.F. Proteins and Nucleic Acids, Elsevier, Amsterdam, 1962
  • Perutz MF (1969). "The haemoglobin molecule". Proceedings of the Royal Society of London. Series B 173 (31): 113-40. PMID 4389425
  • Dogonadze R.R. and Urushadze Z.D. Semi-Classical Method of Calculation of Rates of Chemical Reactions Proceeding in Polar Liquids.- J.Electroanal.Chem., 32, 1971, pp. 235-245
  • Volkenshtein M.V., Dogonadze R.R., Madumarov A.K., Urushadze Z.D. and Kharkats Yu.I. Theory of Enzyme Catalysis.- Molekuliarnaya Biologia (Moscow), 6, 1972, pp. 431-439 (In Russian, English summary)

[edit] See also

[edit] External links

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