Betaxolol

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Betaxolol chemical structure
Betaxolol
Systematic (IUPAC) name
1-[4-[2-(cyclopropylmethoxy)
ethyl]phenoxy]-3-
(1-methylethylamino)propan-2-ol
Identifiers
CAS number 63659-18-7
ATC code C07AB05 S01ED02
PubChem 2369
DrugBank APRD00245
Chemical data
Formula C18H29NO3 
Mol. weight 307.428 g/mol
Pharmacokinetic data
Bioavailability 89%
Metabolism Undocumented
Half life 14-22hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(AU) C(US)
Legal status

℞ Prescription only
Routes oral, ocular

Betaxolol (trade names Betoptic, Betoptic S, Lokren) is a selective beta1 receptor blocker used in the treatment of hypertension and glaucoma. Being selective for beta1 receptors, it typically has fewer systemic side effects than non-selective beta-blockers, for example, not causing bronchospasm (mediated by beta2 receptors) as timolol may. Betaxolol also shows greater affininty for beta1 receptors than metoprolol. In addition to its effect on the heart, betaxolol reduces the pressure within the eye (intraocular pressure). This effect is thought to be caused by reducing the production of the liquid (which is called the aqueous humor) within the eye. The precise mechanism of this effect is not known. The reduction in intraocular pressure reduces the risk of damage to the optic nerve and loss of vision in patients with elevated intraocular pressure due to glaucoma.

Betaxolol was approved by the U.S. Food and Drug Administration (FDA) for ocular use as a 0.5% solution (Betoptic) in 1985 and as a 0.25% solution (Betoptic S) in 1989.


Beta blockers (C07) edit

Non-selective β antagonists (C07AA) edit

Metipranolol, Nadolol, Oxprenolol, Penbutolol, Pindolol, Propranolol, Timolol, Sotalol

β1 antagonists (cardioselective) (C07AB) edit

Atenolol, Acebutolol, Betaxolol, Bisoprolol, Esmolol, Metoprolol, Nebivolol

Mixed α1/β antagonists (C07AG) edit

Carvedilol, Labetalol


Antiglaucoma preparations and miotics (S01E) edit
Sympathomimetics:

Apraclonidine, Brimonidine, Clonidine, Dipivefrine, Epinephrine
Parasympathomimetics:

Aceclidine, Acetylcholine, Carbachol, Demecarium, Echothiophate, Fluostigmine, Neostigmine, Paraoxon, Physostigmine, Pilocarpine
Carbonic anhydrase inhibitors:

Acetazolamide, Brinzolamide, Diclofenamide, Dorzolamide, Methazolamide
Beta blocking agents:

Befunolol, Betaxolol, Carteolol, Levobunolol, Metipranolol, Timolol
Prostaglandin analogues:

Bimatoprost, Latanoprost, Travoprost, Unoprostone
Other agents:

Dapiprazole, Guanethidine
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