Beta-D-glucan
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β-D-glucan (properly known as (1→3)β-D-glucan, but also incorrectly called 1,3-β-D-glucan or even just glucan) forms part of the cell wall of certain medically important fungi, especially Aspergillus species. An assay to detect the presence of (1→3)β-D-glucan in the blood has been produced by Fungitell and is marketed as a means of diagnosing invasive fungal infection in patients.[1][2][3]
One of the limitations of the assay is the presence of fungal contaminants in amoxicillin-clavulanate[4] and piperacillin-tazobactam[5] which may result in false-positive results in those patients receiving these antibiotics.
[edit] References
- ^ Obayashi T, Yoshida M, Mori T, et al. (1995). "Plasma (13)-beta-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes". Lancet 345: 17–20.
- ^ Ostrosky-Zeichner L, Alexander BD, Kett DH, et al. (2005). "Multicenter clinical evaluation of the (1→3)β-D-glucan assay as an aid to diagnosis of fungal infections in humans". Clin Infect Dis 41: 654–659.
- ^ Odabasi Z, Mattiuzzi G, Estey E, et al. (2004). "Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome". Clin Infect Dis 39: 199–205.
- ^ Mennink-Kersten MASH, Warris A, Verweij PE (2006). "1,3-β-D-Glucan in patients receiving intravenous amoxicillin–clavulanic acid" 354 (26): 2834–2835.
- ^ Sulahian A, Touratier S, Ribaud P (2003). "False positive test for aspergillus antigenemia related to concomitant administration of piperacillin and tazobactam". N Engl J Med 349: 2366–2367.
