Benzydamine

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Benzydamine
Systematic (IUPAC) name
?
Identifiers
CAS number	642-72-8
ATC code	A01AD02 G02CC03 M01AX07 M02AA05
PubChem	65464
Chemical data
Formula	C19H24N3O
Mol. weight	282
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties providing both rapid and extended pain relief as well as a significant anti-inflammatory treatment for the painful inflammatory conditions of the mouth and throat.

It selectively binds to inflamed tissues is virtually free of any adverse systemic effects.

It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.

In dosages of 750 mg to 2000 mg it is a hallucinogen and CNS stimulant.

It is available in a mouth wash named Tantum Verde across Europe. In the UK it is sold by 3M as Difflam Spray. Its high cost (about £7 a bottle) makes it less attractive than the cheaper method of gargling aspirin.

[edit] Indications

Odontostomatology: gingivitis, stomatitis, glossitis, aphthous ulcers, dental surgery and oral ulceration due to radiation therapy.

Otorhinolaryngology: pharyngitis, tonsillitis, post-tonsillectomy, radiation or intubation mucositis.

[edit] Contraindications

There are no contraindications to the use of Benzydamine except for known hypersensitivity.

[edit] Side effects

Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur. Benzydamine in dosages 750 mg to 2000 mg is a hallucinogen and CNS stimulant, popular in Poland and Brazil (sold by prescription under the name "Benflogin")