Battle of Issus (disambig)
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- In the Battle of Issus in 333 BC Alexander the Great of Macedonia defeated Darius III of Persia.
- The battle fought between Roman Emperor Septimius Severus and usurper Pescennius Niger, see Battle of Issus (194).
- The battle fought between Roman Emperor Heraclius and Sassanid Empire, see Battle of Issus (622)[1].