Basiliximab

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Basiliximab
Systematic (IUPAC) name
Chimeric murine/human anti-CD25 antibody
Identifiers
CAS number 152923-56-3
ATC code L04AA09
PubChem  ?
DrugBank BTD00073
Chemical data
Formula C6378H9844N1698O1997S48
Mol. weight 143801.3 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Basiliximab (Simulect) is a chimeric mouse-human monoclonal antibody to the IL-2Rα receptor of T cells.[1] It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a Novartis Pharmaceuticals product[2] and was approved by the Food and Drug Administration (FDA) in 1998.[3]

It is given in two doses, the first within 2 hours of the start of the transplant operation and the second 4 days after the transplant. These saturate the receptors and prevent T cell activation and thus prevent formation of antibodies against the transplant.

Like the similar drug daclizumab, basiliximab reduces the incidence and severity of acute rejection in kidney transplantation without increasing the incidence of opportunistic infections. In the United Kingdom, the National Institute for Health and Clinical Excellence has recommended its use be considered for all kidney transplant recipients.

[edit] References & Notes

  1. ↑  IL-2Rα receptor is also known as the CD25 T-cell antigen
  2. ↑  Novartis product page for Simulect (basiliximab for injection) . Retrieved 2005-03-09.
  3. ↑  Waldman, Thomas A. (2003). Immunotherapy: past, present and future. Nature Medicine 9, 269-277.


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Immunosuppressants (L04) edit

Abetimus, Adalimumab, Afelimomab , Anakinra, Alefacept, Antilymphocyte immunoglobulin (horse), Antithymocyte immunoglobulin (rabbit) , Azathioprine, Basiliximab, Ciclosporin, Daclizumab, Efalizumab, Etanercept, Everolimus, Gusperimus , Infliximab, Leflunomide, Methotrexate , Muromonab-CD3 , Mycophenolic acid, Natalizumab, Pimecrolimus, Tacrolimus, Thalidomide, Sirolimus
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