User:Barnkim
From Wikipedia, the free encyclopedia
[edit] Selected anniversaries
December 15: Hanukkah begins at sunset (Judaism, 2006); Zamenhof Day
- 1791 - The first ten amendments to the United States Constitution (pictured), collectively known as the United States Bill of Rights, were ratified.
- 1891 - James Naismith introduced the first version of basketball, with thirteen rules and nine players on each team.
- 1961 - Former Nazi leader Adolf Eichmann was sentenced to death after being found guilty on fifteen criminal charges, including war crimes and crimes against humanity.
- 1994 - The web browser Netscape Navigator 1.0 was first released.
- 1995 - The European Court of Justice handed down the Bosman ruling, allowing footballers in the European Union to freely transfer from one UEFA Federation to another at the end of their contracts.
Recent days: December 14 – December 13 – December 12
[edit] Did you know...
From Wikipedia's newest articles:
- ...that the Certosa di Pavia (pictured) was commissioned by Gian Galeazzo Visconti to be built halfway between his two courts in Milan and Pavia?
- ...that Jason Bedrick, a New Hampshire state representative, is that state's first Orthodox Jewish elected official?
- ...that Chiri Yukie prepared the first Japanese translations of several traditional Ainu yukar as a teenager?
- ...that the Vedic Mathematics genre was revived after Hindu Shankaracharya Jagadguru Swami Sri Bharati Krishna Tirthaji Maharaja rediscovered it in the form of sixteen sutras?
- ...that the Department of State Lands is one of Oregon's oldest government agencies?
- ...that on October 5, 1914, a French Voisin III pilot scored the first air-to-air kill of World War I?
- ...that Broadway actress Evelyn Hoey was found shot dead in the bedroom of Henry H. Rogers's grandson in 1935?
- ...that Julien Wiener is the only Jewish Australian Test cricketer?
- ...that a wooden grain elevator is the only building still operational in Boyd, Oregon?
[edit] Today's featured article
Enzyme inhibitors are molecules that bind to enzymes and decrease their activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Inhibitor binding is either reversible or irreversible. Irreversible inhibitors usually react with the enzyme and change it chemically. These inhibitors modify key amino acid residues needed for enzymatic activity. In contrast, reversible inhibitors bind non-covalently and different types of inhibition are produced depending on whether these inhibitors bind the enzyme, the enzyme-substrate complex, or both. Their discovery and improvement is an active area of research in biochemistry and pharmacology. A medicinal enzyme inhibitor is often judged by its specificity (its lack of binding to other proteins) and its potency (its dissociation constant, which indicates the concentration needed to inhibit the enzyme). A high specificity and potency ensure that a drug will have few side effects and thus low toxicity. Enzyme inhibitors also occur naturally and are involved in the regulation of metabolism. (more...)
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