Auwers synthesis
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The Auwers synthesis in organic chemistry is a classic organic synthesis of a flavonol first reported by K. Auwers in 1908 [1].
The first step in this procedure is a acid catalyzed aldol condensation between benzaldehyde and a 3-oxypentanone to a o-hydroxychalcone. Bromination of the alkene group gives a dibromo-adduct which rearranges to the flavonol by reaction with potassium hydroxide
[edit] See also
- Flavonols can also be obtained in the Algar-Flynn-Oyamada reaction and the Allan-Robinson reaction.
[edit] References
- ^ Hassner, A., Stumer, C., Organic Synthesis Based on Name Reactions: 2. nd. Ed. Tetrahedron Organic Chemistry Series, Volume 22 Pergamon, Oxford ISBN 0-08-043260-3
