Arkansas Highway 159

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Highway 159 is a north-south state highway in extreme southeast Arkansas. Its northern terminus is at U.S. Route 65 and U.S. Route 82 at Chanticleer, Arkansas. Its southern terminus is at the Louisiana State Line where it becomes Louisiana Highway 17.

Between Chanticleer and Eudora, Arkansas, Highway 159 follows the original 1926 alignment of U.S. 65.