Antistreptolysin O titre

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Antistreptolysin O titre (ASO titre or ASOT) - titre of (serum) antistreptolysin O antibodies; a blood test used to assist in the diagnosis of a streptococcal infection or indicate a past exposure to streptococci.

The ASOT helps direct the antimicrobial treatment and is used to assist in the diagnosis of scarlet fever, rheumatic fever and post infectious glomeruonephritis.

A positive test usually >100 unit/mL for preschoolers and >200 units/mL for others, but normal ranges vary from laboratory to laboratory.[1]

The false negatives rate is 20-30%.[2] If a false negative is suspected then an anti-DNase B titre should be sought. False positives can result from liver disease and tuberculosis.[3]

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