Talk:Angiogenesis
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Citation This page was cited by Harvard Journal of Law & Technology |
[edit] Proper Terminology and Mechanisms
I am studying microvasculature remodeling as a result of exercise at the University of Virginia and noticed that this page was lacking in general mechanisms of angiogenesis. Angiogenesis refers only to the changes in capillaries, just a terminology issue. I have outlined many of the chemical mechanisms relating to angiogenesis. Xwingjedi14 06:50, 14 December 2005 (UTC)
[edit] How important is an increased tumor cell mutation rate?
There are some good examples of increased mutation rate in certain cancers, but I am not sure that it has been established that a high mutation rate is required for angiogenesis.
The article Genetic instability and the evolution of angiogenic tumor cell lines (review) claims support from mathematical models for the idea that faster mutation is important.
Other articles such as Angiogenesis and the role of epigenetics in metastasis seem to point towards a need to investigate a combination of mutational and epigenetic mechanisms.
A recent review article Genetic hits and mutation rate in colorectal tumorigenesis: versatility of Knudson's theory and implications for cancer prevention says: "The challenges ahead are to define the number of genetic hits necessary for conversion of a normal cell into a cancer cell and to determine whether the observed increase in the mutation rate (mutator phenotype) is required."
Is there really any data on the role of tumor cell mutation rate in angiogenesis?
Removed reference to evolution at cellular level. This is impossible (how are the selected changes to be passed to the next generation?), evolution only occurs in populations of whole organisms. Try to use more accurate terminology please.--Alun 07:37, 29 Apr 2005 (UTC)
[edit] New Research Suggests Tumors Engender Development of Metastatic Niche (Angiogenesis) Prior to Actual Metastasis
A recent article in Nature VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche suggests that angiogenesis occurs before metastasis and that the cancer mestasizes to the site of the angiogenisis.
