Talk:Amyloid

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Contents 1 IAPP 2 "links" change 3 2nd paragraph 4 Amyloidosis 5 Cross-polymerisation? 6 English please? 7 Removed section: 8 Unusual cluster among Pennsylvania politicians 9 Prion peer review 10 Amyloid TYPE fibres 11 Cross-beta

[edit] IAPP

There are amyloid deposits of IAPP aggressively taking over beta-cell mass in estimated 80% of Type-two diabetes cases... Whether or not IAPP *causes* diabetes is up to debate, but, the deposits are definitely there. This is generally the case for all amyloidoses; whether or not the amyloid peptide is the causative agent is unknown. - (unsigned)

Reasonable enough emendation. I missed this explanation at first: sorry, my oversight, but a "see talk" or some similar notation in an edit summary would make it harder to overlook. - Nunh-huh 06:31, 5 Jul 2004 (UTC)

[edit] "links" change

So the research shows that there is a link, whether or not it holds up to further scrutiny is (of course) still up in the air. The existence of a link, is, therefore, undisputable. Whether or not it's "real", that is, not an artifact of whatever methodologies were being used, is a different question. -Unknown

[edit] 2nd paragraph

Could someone please rewrite the 2nd paragraph so that it is a little more intelligible to the non-specialist? ike9898 12:59, Aug 12, 2004 (UTC)

[edit] Amyloidosis

I would like to see an expanded discussion of what Amyloidosis (which redirects here) is! — brighterorange (talk) 18:26, 25 September 2005 (UTC)

Perhaps that should be a seperate page. Amyloid is the substance, while amyloidosis is the disease entity. That page itself should distinguish between the primary amyloidoses (AL amyloidosis, transthyretin-, ApoB-, lysozyme- or fibrinogen-related hereditary amyloid), AA amyloidosis secondary to chronic inflammatory conditions such as rheumatoid arthritis and FMF and some organ-specific amyloid. Clinical info from this page can then be merged there. Would you like to take the first step, Brighterorange? JFW | T@lk 19:12, 25 September 2005 (UTC)

I see the invitation is still open. Since amyloidosis desparately needs a page of its own, perhaps I will start one up after I finish a few of the more developed projects. InvictaHOG 21:17, 3 August 2006 (UTC)

[edit] Cross-polymerisation?

It says cross polymerisation is the mechanism of prion replication. What is cross-polymerisation and how is it known that prions replicate that way? It's not a term I've heard of. --Purple 22:36, 7 February 2006 (UTC)

OK I think I get that it's referring to molecules from one species seeding fibrils of the same protein from another species...--Purple 02:59, 11 March 2006 (UTC)

Based on the term that sounds in the ballpark, it should go in :) Tyciol 11:54, 12 October 2006 (UTC)

[edit] English please?

I think a paragraph needs to be added to explain simply the effects and causes of this disease. Recovery statistics, treatments, etc. If this information is already on the page, it is too dificult to understand. Druidan 21:49, 1 May 2006 (UTC)

The problem is that this is primarily an article about a set of proteins, not a disease. We need to work to bring about a page on amyloidosis itself. InvictaHOG 21:15, 3 August 2006 (UTC)

This makes sense, it's kind of like wanting an article for atherosclerosis on the cholesterol article. This should remain neutral to simply describing the physical properties, with a note leading to further emphasis on the disease it causes when building up extracellularly, especially in brain tissue for Alzheimers seeing as how popular that is to talk about. Tyciol 11:54, 12 October 2006 (UTC)

Amyloidosis is a fascinating disease which can more than fill its own article. Bits of both amyloid and amyloidosis will most likely end up on the other page, but separating the clinical syndrome and causes from the biochemistry seems like a natural break. It will probably improve both articles to limit the focus. Your cholesterol/atherosclerosis analogy is a good one! InvictaHOG 12:51, 12 October 2006 (UTC)

We do need a page about the disease, or at least a blurb explaining a bit of this in English. I love you, biology-people, but you crazy. [Too lazy to sign in.] -Unknown

It's still on my list. Sorry, I'll probably work on it in November! InvictaHOG 01:33, 11 October 2006 (UTC)

Bio guys sure are crazy, but hey, comes with figuring out how you're basically descended from bacteria :p Tyciol 11:54, 12 October 2006 (UTC)

Most people are crazy, in my experience. InvictaHOG 12:51, 12 October 2006 (UTC)

[edit] Removed section:

This talks about amyloidosis (and not amyloid), and does not specify what type of amyolidosis (by default AA amyloidosis is assumed, but the paragraph makes no reference). So should be stricken due to ambiguity, and (even if not) limited scope. If anywhere on wiki, it should go in the article pertaining to the particular type of amyloidosis observed in the cluster. Also some figures with the number of people in the class of "pennsylvania politicians" should be provided, along with population rates. For example, "unusual cluster of politicians with diabetes amyloid" might not be so unusual.

[edit] Unusual cluster among Pennsylvania politicians

In the mid-1980s, Pittsburgh Mayor Richard S. Caliguiri was diagnosed with amyloidosis. Within a few years, three of Pennsylvania's most prominent political leaders were also afflicted with the disorder. Caliguiri, longtime Erie Mayor Louis Tullio, and Governor Robert P. Casey were all diagnosed with the incurable and usually fatal disease. All three eventually died from it.

[edit] Prion peer review

I've nominated the prion article for peer review, any comments welcome here! --Purple 02:59, 11 March 2006 (UTC)

Prions and amyloids are good together? Tyciol 11:54, 12 October 2006 (UTC)

[edit] Amyloid TYPE fibres

There seems to be a tendency amongest microbiologists to refer to all cross-beta type fibres as being amyloid. Amyloid itself was named after the pathological deposits found in humans. Would anyone mind if I stated this in the opening couple paragraphs, and then removed references to fibres such as curli which although cross beta, are not amyloid? --Simon 12:15, 18 August 2006 (UTC)

Sounds good, especially if you can add references! InvictaHOG 12:22, 18 August 2006 (UTC)

The old article used to make a distinction between "biophysicist's" defintion (just beta-sheet) and histopathological definition. I've reverted this edit, especially since the histopathological definition has come into question since Westermark observed IAPP fibrils in an intracellular context in a diabetes mouse model, suggesting that IAPP fibrils (certainly amyloid in the classical definition) start out intracellular and then move to the extracellular milieu.

[edit] Cross-beta

This is mentioned in the article as a key point to explaining what amyloids are, but despite that, it lacks an article. I've honestly no clue, but if no one's going to do it yet, perhaps we can redirect it here, with an explanation of what it is, or theories or whatever, on this page? Tyciol 11:54, 12 October 2006 (UTC)

An Image with an explanation is forthcoming (TaKometer)