Amprenavir

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Amprenavir
Systematic (IUPAC) name
tetrahydrofuran-3-yl [3-[(4-aminophenyl)sulfonyl- (2-methylpropyl) amino] -1-benzyl-2- hydroxy-propyl] aminomethanoate
Identifiers
CAS number	161814-49-9
ATC code	J05AE05
PubChem	65016
DrugBank	APRD00605
Chemical data
Formula	C25H35N3O6S
Mol. weight	505.628 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	90%
Metabolism	?
Half life	7.1-10.6 hours
Excretion	?
Therapeutic considerations
Licence data	EU US
Pregnancy cat.	?
Legal status
Routes	?

Amprenavir (Agenerase®) is a protease inhibitor used to treat HIV. It was approved by the Food and Drug Administration on April 15, 1999, for twice-a-day dosing instead of needing to be taken every eight hours. The convenient dosing came at a price, as the dose required is 1,200mg, delivered in eight very large gel capsules. Production of amprenavir was discontinued by the manufacturer December 31, 2004.

Antivirals (primarily J05A, also S01AD and D06BB) edit

Anti-herpesvirus agents   Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine Anti-influenza agents Amantadine, Oseltamivir, Peramivir, Rimantadine, Zanamivir   Antiretroviral drugs   NRTIs Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine NtRTIs   Tenofovir NNRTIs   Efavirenz, Delavirdine, Nevirapine PIs Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir Fusion inhibitors Enfuvirtide   Other antiviral agents Adefovir, Fomivirsen, Imiquimod, Inosine,Interferon, Podophyllotoxin, Ribavirin, Viramidine