Alprostadil

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Alprostadil chemical structure
Alprostadil
Systematic (IUPAC) name
7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] heptanoic acid
Identifiers
CAS number 745-65-3
ATC code C01EA01 G04BE01
PubChem 149351
DrugBank APRD00785
Chemical data
Formula C20H34O5
Mol. weight 354.481 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Alprostadil is the pharmaceutical name for prostaglandin E1. It is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. (Dorland's)

It is also used in maintaining a patent ductus arteriosus in the fetus. This is primarily useful when there is threat of premature closure of the ductus arteriosus.

[edit] References

Dorland's Medical Dictionary. alprostadil. Retrieved on September 12, 2006.


Urologicals (G04) edit
Acidifiers:

Ammonium chloride, Calcium chloride

Urinary antispasmodics:

Darifenacin, Emepronium, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium

For erectile dysfunction:

Alprostadil, Apomorphine, Moxisylyte, Papaverine, Phentolamine, Sildenafil, Tadalafil, Vardenafil, Yohimbine

Other urologicals:

Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Phenazopyridine, Phenyl salicylate, Succinimide

For benign prostatic hypertrophy:

5α-reductase inhibitors: Dutasteride, Finasteride
Alpha blockers: Alfuzosin, Doxazosin, Tamsulosin, Terazosin
Herbals: Pygeum africanum, Serenoa repens