Talk:Adrenal insufficiency

From Wikipedia, the free encyclopedia

Congenital Adrenal Hyperplasia is th primary cause of Adrenal Insufficiency. Stop deleting links when you haven't a clue about the subject!! I have two kids with CAH and people will come here looking for info about it. Dannycarlton 23:32, 6 June 2006 (UTC)

As I explained on my talkpage in response to your message, the link belongs on congenital adrenal hyperplasia. I do have a clue about the subject. The vast minority of people with adrenal insufficiency have CAH. JFW | T@lk 23:49, 6 June 2006 (UTC)

From eMedicine "Primary adrenocortical insufficiency is an uncommon disorder with an incidence in Western populations near 50 cases per 1,000,000 persons." Since, in the general population about one person in 50 carries the CAH gene (trait). That would make the instance of CAH one in every 2,500. It's actually a bit more rare than that, but obviously the figures account for quite a significant number of those with Adrenal Insufficieny. Dannycarlton 00:06, 7 June 2006 (UTC)

Danny: the link belongs on the CAH page. Most adrenal insufficiency is caused by steroid therapy and autoimmune causes. Have you reviewed our external links policy yet? JFW | T@lk 00:12, 7 June 2006 (UTC)

Please refrain from editing topics that you know so little about. You are one of the reasons Wikipedia has such a horrible reputation. I have been deeply involved in CAH for over 12 years now, and you apparently looked it up once. Stop turning WP into your personal site and let people offer information when they know the topic. Dannycarlton 02:05, 7 June 2006 (UTC)

DNFTT. JFW | T@lk 02:16, 7 June 2006 (UTC)

[edit] Waterhouse-Friderichsen syndrome?

This entry lists Waterhouse-Friderichsen syndrome as an adrenal insufficiency condition, but the page of that syndrome says that "It is sometimes said that the hemorrhage in Waterhouse-Friderichsen syndrome causes an acute adrenal insufficiency, but this is inaccurate, since blood cortisol levels are not decreased. The shock, purpura and intravascular clotting are probably the result of an endotoxin mediated immune reaction caused by sepsis." so it seems like there's a contradiction. DiamonDie 11:32, 30 August 2006 (UTC)

In every source I've seen, not one has mentioned sepsis as probable. Neither have I found anything to suggest that cortisol levels are normal in cases Waterhouse-Friderichsen syndrome In fact, it is likely that this statement is entirely speculative. I can find no sources to back up the statement. I have suggested editing the article on Waterhouse-Friderichsen syndrome. From [1]: "24 patients (among 35 clinical cases) with meningococcal Waterhouse-Friderichsen syndrome were submitted to pathologic anatomical examinations (including 18 microscopic investigations). Two aspects were found: 12 cases of mild suprarenal hemorrhage (histological evidence only), but associated with massive degeneration of the adrenocortical cells, leptomeningitis, distinct thymic hypertrophy with microthrombi in various organs. The other 12 cases presented massive bilateral suprarenal hemorrhage with medium status thymo-lymphaticus and distinct capillary thromboses in all organs investigated (consumptive coagulopathy)."

Tiny.ian 00:38, 16 September 2006 (UTC)