Talk:Actin

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I think actin is worthy of its own article. It can certainly be expanded with more information into a much longer article. The section in cytoskeleton can discuss actin briefly, then link here for more in-depth information. What does everyone else think? — Brim 07:10, Nov 26, 2004 (UTC)

I agree. Just see: "What links here" and compare to microfilaments. Its definately worth its own article, and microfilaments shouldn't be merged with cytoskeleton either. Nina 09:52, 26 Nov 2004 (UTC)

I believe that Actin and microfilaments should be merged. They both talk about the same thing: actin microfilaments. Strictly speaking "actin" refers only to the monomers that make up an actin microfilament. Tycho 18:40, 26 Nov 2004 (UTC)

I think merging actin and microfilaments would be acceptable, with microfilaments being discussed in the Actin article. — Brim 07:01, Nov 27, 2004 (UTC)

Alright - Actin is not a single protein but a whole protein family as so far 6 different actin genes - [ACTA1], [ACTA2], [ACTB], [ACTC], [ACTG1], [ACTG2] - that are active, plus several pseudogenes, have been discovered in humans only (i bet there are many more in the rest of the live world). So, the info about the actin(s) shoud be part of the [actin] section of Cytoskeleton, where its function should be explained and where links to all the members to the family should be given, which i will do, unless someone else has already done it. BorisTM 07:48, 25 October 2005 (UTC)

[edit] Source Uncited

"Recent studies have also suggested that actin network on the cell cortex serve as barriers for molecular diffusion within the plasmic membrane." (last line in the article)

If someone could locate and cite these studies, it would be helpful.

actin based motility need to be mentioned in this article. 128.255.106.132 23:03, 11 May 2006 (UTC)

You are correct vesicle fusion and several processes including adhesion need actin, also the gel-sol state is essential for amoeboid movement. There is no mention of actin treadmilling either. Weak article altogether.GetAgrippa 13:59, 11 October 2006 (UTC)

[edit] Incorrect statement

"In the first case, one end of myosin is bound to the plasma membrane while the other end walks towards the plus end of the actin filament." Actin attaches to focal adhesions, adherant plaques, membrane specializations not myosin attaching to plasma membrane. Well there are novel myosins and one that apparently attach to vesicles for movement.GetAgrippa 22:16, 10 October 2006 (UTC)

You might be right. Do you want to edit the article? Please add sources if you have any. Also muscle contraction and contractile bundles are a bit mixed in that subsection. A reader might not get the distinction between the two. --Splette ^Talk 22:20, 10 October 2006 (UTC)

I am busy with other articles, but the discussion would include actinin,dystrophin,vinculin, and also the intermediate filaments desmin and/or vimentin. GetAgrippa 17:54, 11 October 2006 (UTC)