Acenocoumarol


Acenocoumarol
Systematic (IUPAC) name
2-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-4H- chromen-4-one
Identifiers
CAS number	152-72-7
ATC code	B01 AA07
PubChem	9052
Chemical data
Formula	C₁₉H₁₅N O₆
Mol. weight	353.326 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	8 to 11 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Oral

Acenocoumarol is a anticoagulant that functions as a vitamin K antagonist (like warfarin).

It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome®.

[edit] External links

DDB 29202
Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 673-6. PMID 15613922.
Lengyel M (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 2619-21. PMID 15724697.
Ufer M (2005). "Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 1227-46. PMID 16372822.
Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 183-7. PMID 16611310.

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Antithrombotics (thrombolytics, anticoagulants, and antiplatelet drugs) (B01) edit
Vitamin K antagonists:	Acenocoumarol, Clorindione, Dicumarol (Dicoumarol), Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin
Heparin group (Platelet aggregation inhibitors):	Antithrombin III, Bemiparin, Dalteparin, Danaparoid, Enoxaparin, Heparin, Nadroparin, Parnaparin, Reviparin, Sulodexide, Tinzaparin
Other Platelet aggregation inhibitors:	Abciximab, Acetylsalicylic acid (Aspirin), Aloxiprin, Beraprost, Ditazole, Carbasalate calcium, Cloricromen, Clopidogrel, Dipyridamole, Epoprostenol, Eptifibatide, Indobufen, Iloprost, Picotamide, Prasugrel, Ticlopidine, Tirofiban, Treprostinil, Triflusal
Enzymes:	Alteplase, Ancrod, Anistreplase, Brinase, Drotrecogin alfa, Fibrinolysin, Protein C, Reteplase, Saruplase, Streptokinase, Tenecteplase, Urokinase
Direct thrombin inhibitors:	Argatroban, Bivalirudin, Dabigatran, Desirudin, Hirudin, Lepirudin, Melagatran, Ximelagatran
Other antithrombotics:	Dabigatran, Defibrotide, Dermatan sulfate, Fondaparinux, Rivaroxaban
Non-medicinal:	Citrate, EDTA, Oxalate